Endocrine Abstracts

A 32-year-old male was referred by his GP with a 6-month history of lethargy, erectile dysfunction, weight gain, acne and hypertension. He denied exogenous steroid usage and had no other past medical history. On examination, he had classical features of Cushing’s including moon face, central adiposity, proximal muscle weakness and purple striae.Investigations confirmed Cushing’s from a pituitary source as shown in the table below. MRI pituitary...

Hypercalcemia is commonly caused by primary hyperparathyroidism. Other causes of hypercalcaemia can be seen in the clinical setting, and it is important to consider these alternative diagnoses as the management differs dramatically from the management of primary hyperparathyroidism. We present a series of four patients presenting with four different granulomatous conditions causing hypercalcaemia. These were secondary to Tuberculosis, Sarcoidosis, Wegener’s granulomatosis...

A 73 year old female presented with collapse secondary to hypoglycaemia. Investigations are summarised in the table attached. In the presence of raised tumour markers and a raised IGF2/IGF1 ratio, carcinomatosis was considered as the most likely underlying diagnosis. Nutritional support was arranged with additional carbohydrate dietary intake advised. She responded well with reduced hypoglycaemic frequency of hypoglycaemia. Investigations for underlying carcinoma were unable t...

61-year-old previously fit and healthy female presented with one-week history of confusion and altered consciousness. There was no history of fever, headache or limb weakness. She was dehydrated, Glasgow Coma Scale score was 11/15, pupils were equal and reactive to light bilaterally and rest of examination was unremarkable. Initial investigations are outlines in Table 1. X-ray-chest showed mediastinal lymphadenopathy and CT head was unremarkable. She was initially treated for ...

Background: We previously published data for short-term outcomes in patients with SIADH-related hyponatraemia unresponsive to fluid restriction and treated with tolvaptan. In light of concerns over longer-term side-effects we have revisited the topic and extended both group size and follow-up period to determine longer-term safety and treatment implications.Aims/methods: We report ongoing treatment outcomes (case-note review) for 25 patients (age 71&#177...